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Controlled Fabrication of Microporous Annealed Particle (MAP) Gel: Engineering a Method of Automated Infusion and Mixing to Generate a Monodisperse Population of Microparticles

Presenters Name: 
Jan Oliver Viyar
Co Presenters Name: 
Primary Research Mentor: 
Don Griffin
Secondary Research Mentor: 
11:00 - 12:15
Time of Presentation: 
2019 - 11:00am to 12:15pm
Newcomb Hall Ballroom
Presentation Type: 
Presentations Academic Category: 
Grant Program Recipient: 
Not a Recipient

Microporous annealed particle (MAP) gel has been shown to act as an effective scaffold for tissue regeneration by providing a three-dimensional structure in which cells can proliferate and tissue can subsequently regrow. When the gel microparticle size distributions are tightly tuned, the microporous structure, degradation rates, and diffusion rates of encapsulated payloads can be better controlled. Current approaches to fabricating MAP gel require a tradeoff between particle uniformity and speed of production. A novel approach combining controlled infusion with mixing has shown the potential for near perfect uniformity without sacrificing throughput. Monodisperse (PDI ≲ 1.1) microparticle populations were fabricated in the size range of 30 – 120 μm via the manipulation of infusion rates and mixing speeds used in forming water/oil (W/O) emulsions.