Over the past decade, there has been a transition from conventional biomaterials to materials with injectability potential; both for minimally invasive therapeutics and for 3D printing applications.To address this problem, we have designed a biomaterial capable of recapitulating the complex extracellular matrix (ECM) microenvironment and capable of injectability. This work, done in the Caliari Lab in Chemical Engineering, uses hyaluronic acid (HA) as a material backbone due to its natural abundance in the ECM, and therefore biocompatibility, and due to its tunability via modifications to the pendant groups. Material injectability was accomplished via the non-covalent association of supramolecular chemical complexes which form reversible hydrophobic associations. The supramolecular association involves a guest molecule and a host molecule, which when conjugated separately to the HA backbone create a viscoelastic and injectable hydrogel. Oscillatory shear rheology was used to characterize the supramolecular interactions of the final hydrogel. The ratio of guest to host molecule abundance was investigated to determine the ideal ratio between the groups. The guest-host hydrogel was also covalently crosslinked to encapsulate cells and observe material biocompatibility. Live/dead staining was performed in addition to staining for cell process extensions indicative of cell spreading. Ultimately, we were able to synthesize a biocompatible hydrogel capable of supporting cell growth and migration and capable of injectability applications.