Metal-organic framework (MOF) materials are a novel organic-nonorganic hybrid formed from relatively inexpensive starting materials. Known for their high surface area and porosity, they have a wide range of applications in catalysis, gas separation, and drug delivery. Recent reports have shown MOFs are effective at capturing particles with the most adverse health effects, or those smaller than 2.5 μm (PM2.5). In this study, three methods of attaching prototypical MOFs to cotton fabric were tested to create low cost and versatile air filters. We demonstrate MOF attachment to cotton substrates can be enhanced by a carboxymethylation surface treatment when submerging substrates into MOF suspensions. Furthermore, we demonstrate a layer by layer (LbL) approach and spray coating can be used for in-situ growth on cotton substrates. MOF deposition and growth on substrates was confirmed through scanning electron microscopy (SEM), Brunauer – Emmett – Teller (BET) isotherm measurements, and massing samples before and after loading. MOF loading was calculated through weighted averages of surface area between our highly porous MOFs and nonporous organic substrate. Finally, we show that MOF loading is a function of coating steps if done through the in-situ approach (LbL or spray), and particle suspension concentration if done through suspension processing and surface treatment. Future work will focus on fine-tuning MOF deposition and attachment on substrates and testing filtration efficacy as a function of MOF mass loading on the substrate.