The winners of the International Society for Computational Biology’s Overton Award, an annual award, are considered to be major contributors to the field of bioinformatics and are recognized for an outstanding accomplishment to the field. The field of bioinformatics is an interdisciplinary field that incorporates knowledge from biology , computer science , mathematics, and statistics. The goal of this study was to identify overlapping relationships or commonalities that contributed to success in Bioinformatics by observing mentorships and collaborations among awardees. We postulated that there would be evident networks of collaboration and success that could be traced to innovation in this field. To answer this question, we identified the seventeen past winners and compiled a network of their earliest collaborators and mentors. While there are a few crucial associations of mentors and collaborators with awardees, and collaboration among them in cutting edge facilities led to significant research in this field, a majority of the winners are disconnected from this apparent network. This may be because bioinformatics is still somewhat in its infancy, or because the International Society for Computational Biology was only founded in 1997. It appears, however, that the winners of more recent years have more common mentors and collaborators, and so if this trend continues the results may be more applicable in later years.